MCCC1

Across TCGA patient cohorts, MCCC1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCCC1-associated genes across cancer lineages are 14-3-3_beta, eEF2, and eIF4E. Each is linked with MCCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCCC1-to-partner and partner-to-MCCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MCCC1-low versus MCCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCCC1→partner) and Y-score (partner→MCCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.095	-3.673	.007	.001	3	2
UCEC	eEF2 →	+0.390	+2.584	.001	.010	3	2
UCEC	eIF4E →	+0.155	+2.000	.038	.003	3	2
UCEC	GAPDH →	+0.439	+1.700	.020	.040	3	2
UCEC	JNK_pT183_Y185 →	-0.155	-1.349	.009	.037	3	2
UCEC	MEK1 →	+0.559	+2.874	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

14-3-3_beta by MCCC1 expression — UCEC

Explore this box plot interactively →