MCCC1

Across TCGA cell cohorts, MCCC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,948 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MCCC1-associated GO terms across cancer lineages are L-leucine metabolic process, L-leucine catabolic process, and Maintenance of centrosome location. Each is linked with MCCC1 in more than 12 cancer types. Because this analysis shows association rather than direction, both MCCC1-to-partner and partner-to-MCCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-leucine metabolic process grouped by MCCC1-low versus MCCC1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCCC1→partner) and Y-score (partner→MCCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	L-leucine metabolic process →	+0.256	+1.012	<.001	<.001	3	13
LIVER	L-leucine catabolic process →	+0.256	+1.012	<.001	<.001	3	13
LUNG_SCLC	Maintenance of centrosome location →	+0.124	+0.860	.002	.009	3	11
LIVER	Regulation of collagen metabolic process →	-0.176	-0.986	.001	.001	3	11
BREAST	Positive regulation of collagen metabolic process →	-0.137	-0.991	<.001	<.001	3	11
BREAST	Isopentenyl diphosphate biosynthetic process, mevalonate pathway →	+0.145	+0.823	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,948 associations by consensus.

L-leucine metabolic process by MCCC1 expression — LIVER

Explore this box plot interactively →