MCCC1

Across TCGA cell cohorts, MCCC1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MCCC1-associated genes across cancer lineages are RNASE9, MS4A13, and SEL1L2. Each is linked with MCCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCCC1-to-partner and partner-to-MCCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE9 grouped by MCCC1-low versus MCCC1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCCC1→partner) and Y-score (partner→MCCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNASE9 →	+0.029	+5.029	<.001	.006	3	2
LUNG_NSCLC_LUAD	MS4A13 →	+0.131	+5.228	.004	.005	3	2
BLOOD_Lymphoma	SEL1L2 →	+0.033	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	GP9 →	+0.494	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	MYMK →	+0.034	+5.209	.001	.005	3	1
SKIN	SULT6B1 →	+0.102	+3.920	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

RNASE9 by MCCC1 expression — LUNG_SCLC

Explore this box plot interactively →