MCC

Across TCGA pan-cancer cohorts, MCC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MCC data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MCC mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MCC expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where MCC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.635	0.902	.005	12	view →
HNSC	OS	Quartile	II,III,IV	0.918	0.796	.030	6	view →
PDAC	OS	Quartile	II,III,IV	0.481	0.655	.042	2	view →
CCRCC	DFS	Median	III,IV	0.834	0.578	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MCC–LSCC (OS)

Open the LSCC breakdown →