MCC

Across TCGA pan-cancer cohorts, MCC mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MCC’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MCC mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MCC is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and CCRCC are the cancer types where MCC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MCC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.795	<.001	9	view →
LSCC	All	III,IV	−0.309	<.001	6	view →
CCRCC	All	All	+0.183	<.001	3	view →
HNSC	Female	IV	+0.700	.017	1	view →
PDAC	All	III,IV	−0.265	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MCC–LUAD

Open the LUAD breakdown →