MCC

Across TCGA patient cohorts, MCC protein abundance is significantly associated with the RNA expression of many other genes, with 16,376 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MCC-associated genes across cancer lineages are CDCA3, PDGFRB, and NEK2. Each is linked with MCC in more than 5 cancer types. Because this analysis shows association rather than direction, both MCC-to-partner and partner-to-MCC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCC versus CDCA3 in BRCA, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCC→partner) and Y-score (partner→MCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA3 →	-1.217	-0.442	<.001	<.001	3	6
OV	PDGFRB →	+1.227	+0.336	<.001	<.001	3	6
UCEC	NEK2 →	-1.083	-0.383	.001	<.001	3	6
BRCA	EDA2R →	+1.275	+0.492	<.001	<.001	3	6
UCEC	CDCA8 →	-1.058	-0.318	.003	.001	3	6
CCRCC	HMGA1 →	-0.796	-0.436	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,376 associations by consensus.

MCC vs CDCA3 — BRCA

Explore this scatter interactively →