MCC

Across TCGA patient cohorts, MCC protein abundance is significantly associated with the protein abundance of many other proteins, with 21,601 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MCC-associated proteins across cancer lineages are KANK2_S375, CHERP, and SMARCA5. Each is linked with MCC in more than 6 cancer types. Because this analysis shows association rather than direction, both MCC-to-partner and partner-to-MCC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCC versus KANK2_S375 in BRCA, with a Pearson correlation of 0.29.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MCC→partner) and Y-score (partner→MCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KANK2_S375 →	+0.629	+0.389	<.001	<.001	3	7
BRCA	CHERP →	-0.318	-0.427	<.001	<.001	3	6
BRCA	SMARCA5 →	-0.308	-0.377	.002	<.001	3	6
UCEC	SORBS3 →	+0.441	+0.277	<.001	<.001	3	6
OV	MYO1C →	+0.451	+0.367	.003	.001	3	6
BRCA	POLD3 →	-0.512	-0.420	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,601 associations by consensus.

MCC vs KANK2_S375 — BRCA

Explore this scatter interactively →