MCC

Across TCGA patient cohorts, MCC mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCC-associated genes across cancer lineages are Shc_pY317, p38-MAPK_pT180_Y182, and ATM. Each is linked with MCC in more than 2 cancer types. Because this analysis shows association rather than direction, both MCC-to-partner and partner-to-MCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by MCC-low versus MCC-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCC→partner) and Y-score (partner→MCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Shc_pY317 →	-0.145	-2.442	.014	.017	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.269	-1.247	.035	.041	3	3
UCEC	ATM →	-0.366	-2.074	.004	.004	3	3
COAD	mTOR_pS2448 →	-0.130	-1.987	.040	.029	3	2
UCEC	4E-BP1 →	+0.258	+2.415	<.001	.002	3	2
SKCM	eEF2K →	+0.373	+3.012	.026	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Shc_pY317 by MCC expression — COAD

Explore this box plot interactively →