MCC

Across TCGA cell cohorts, MCC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,949 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCC-associated GO terms across cancer lineages are Host-mediated perturbation of viral process, Transcription elongation by RNA polymerase II, and Modulation of process of another organism. Each is linked with MCC in more than 11 cancer types. Because this analysis shows association rather than direction, both MCC-to-partner and partner-to-MCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Host-mediated perturbation of viral process grouped by MCC-low versus MCC-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCC→partner) and Y-score (partner→MCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Host-mediated perturbation of viral process →	+0.082	+1.435	.002	.003	3	12
LIVER	Transcription elongation by RNA polymerase II →	+0.086	+1.874	<.001	<.001	3	10
KIDNEY	Modulation of process of another organism →	+0.077	+0.899	<.001	.006	3	9
BLOOD_Lymphoma	Regulation of RNA splicing →	+0.075	+0.813	<.001	<.001	3	9
KIDNEY	Host-mediated perturbation of symbiont process →	+0.077	+0.899	<.001	.006	3	9
STOMACH	Macroautophagy →	+0.071	+1.129	.002	.009	1	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,949 associations by consensus.

Host-mediated perturbation of viral process by MCC expression — OESOPHAGUS

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