MCAT

Across TCGA pan-cancer cohorts, MCAT mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MCAT data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher MCAT mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MCAT expression acts as an unfavorable survival marker, although some lineages such as GBM and COAD show a favorable association.

GBM, COAD, and HNSC are the cancer types where MCAT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.868	0.770	.005	12	view →
COAD	DFS	Median	III,IV	1.000	0.844	.044	6	view →
HNSC	DFS	Quartile	IV	0.476	0.792	.031	5	view →
CCRCC	OS	Median	All	0.984	0.905	.031	2	view →
LSCC	OS	Quartile	III,IV	0.521	0.938	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MCAT–GBM (OS)

Open the GBM breakdown →