MCAT

Across TCGA patient cohorts, MCAT RNA expression is significantly associated with the protein abundance of many other proteins, with 15,720 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MCAT-associated proteins across cancer lineages are ATXN10, TTLL12, and CCDC134. Each is linked with MCAT in more than 8 cancer types. Because this analysis shows association rather than direction, both MCAT-to-partner and partner-to-MCAT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCAT versus ATXN10 in BRCA, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAT→partner) and Y-score (partner→MCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATXN10 →	+0.410	+0.417	<.001	<.001	3	9
LSCC	TTLL12 →	+0.463	+0.460	<.001	<.001	3	8
PDAC	CCDC134 →	+0.334	+0.388	<.001	<.001	3	6
LSCC	NUP50 →	+0.256	+0.463	<.001	<.001	3	6
OV	POLDIP3 →	+0.496	+0.627	<.001	<.001	3	6
LUAD	RASA2 →	-0.223	-0.483	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,720 associations by consensus.

MCAT vs ATXN10 — BRCA

Explore this scatter interactively →