MCAT

Across TCGA patient cohorts, MCAT protein abundance is significantly associated with the RNA expression of many other genes, with 12,434 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MCAT-associated genes across cancer lineages are CNRIP1, RAB8B, and FLI1. Each is linked with MCAT in more than 6 cancer types. Because this analysis shows association rather than direction, both MCAT-to-partner and partner-to-MCAT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCAT versus CNRIP1 in OV, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAT→partner) and Y-score (partner→MCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNRIP1 →	-0.759	-0.258	<.001	.006	3	7
BRCA	RAB8B →	-0.690	-0.312	<.001	<.001	3	7
COAD	FLI1 →	-0.625	-0.338	<.001	<.001	3	7
OV	PMP22 →	-1.081	-0.371	<.001	<.001	3	6
BRCA	STARD8 →	-0.693	-0.386	<.001	<.001	3	6
OV	SYT11 →	-1.457	-0.354	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,434 associations by consensus.

MCAT vs CNRIP1 — OV

Explore this scatter interactively →