MCAT

Across TCGA patient cohorts, MCAT mutation is significantly associated with the RNA expression of many other genes, with 213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCAT-associated genes across cancer lineages are LLPHP1, BTBD7P2, and CD80. Each is linked with MCAT in more than 1 cancer types. Because this analysis shows association rather than direction, both MCAT-to-partner and partner-to-MCAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LLPHP1 grouped by MCAT-low versus MCAT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAT→partner) and Y-score (partner→MCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LLPHP1 →	+0.103	+4.979	.003	.009	3	2
SKCM	BTBD7P2 →	+0.142	+5.594	<.001	.004	3	2
UCEC	CD80 →	+0.425	+3.354	.001	.005	3	1
UCEC	LINC00544 →	+0.161	+3.186	<.001	.001	3	1
UCEC	AGAP2 →	+0.816	+3.364	<.001	.005	3	1
UCEC	FCRL5 →	+0.678	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 213 associations by consensus.

LLPHP1 by MCAT expression — SKCM

Explore this box plot interactively →