MCAT

Across TCGA patient cohorts, MCAT mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCAT-associated genes across cancer lineages are ERK2, FOXO3a_pS318_S321, and Lck. Each is linked with MCAT in more than 1 cancer types. Because this analysis shows association rather than direction, both MCAT-to-partner and partner-to-MCAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MCAT-low versus MCAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAT→partner) and Y-score (partner→MCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.234	+3.000	.035	.037	3	1
UCEC	FOXO3a_pS318_S321 →	-0.200	-3.000	.005	.037	3	1
UCEC	Lck →	+0.472	+3.000	<.001	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.685	-2.986	.008	.037	3	1
UCEC	PCNA →	+0.301	+3.000	.015	.037	3	1
UCEC	4E-BP1_pT37_T46 →	-0.681	-3.000	.001	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ERK2 by MCAT expression — UCEC

Explore this box plot interactively →