MCAT

Across TCGA cell cohorts, MCAT mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCAT-associated genes across cancer lineages are OR2A5, CFHR2, and REM1. Each is linked with MCAT in more than 1 cancer types. Because this analysis shows association rather than direction, both MCAT-to-partner and partner-to-MCAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A5 grouped by MCAT-low versus MCAT-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAT→partner) and Y-score (partner→MCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR2A5 →	+0.032	+4.922	<.001	.009	3	1
LARGE_INTESTINE	CFHR2 →	+0.057	+5.022	<.001	.002	3	1
LARGE_INTESTINE	REM1 →	+0.044	+4.095	<.001	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.032	+4.169	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR2A5 by MCAT expression — BLOOD_Leukemia

Explore this box plot interactively →