MCAM

Across TCGA patient cohorts, MCAM mutation is significantly associated with the RNA expression of many other genes, with 2,129 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCAM-associated genes across cancer lineages are SNORD116-23, MIR449B, and RPL29P28. Each is linked with MCAM in more than 3 cancer types. Because this analysis shows association rather than direction, both MCAM-to-partner and partner-to-MCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-23 grouped by MCAM-low versus MCAM-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAM→partner) and Y-score (partner→MCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SNORD116-23 →	+0.420	+5.306	<.001	.006	3	4
HNSC	MIR449B →	+0.323	+7.954	<.001	.008	3	2
BLCA	RPL29P28 →	+0.083	+2.544	.003	.006	3	2
LUSC	RNU6-436P →	+0.435	+4.211	.002	.009	3	2
UCEC	CCL4 →	+1.289	+3.021	<.001	<.001	3	2
UCEC	CCL18 →	+1.362	+3.008	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,129 associations by consensus.

SNORD116-23 by MCAM expression — CESC

Explore this box plot interactively →