MCAM

Across TCGA patient cohorts, MCAM mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCAM-associated genes across cancer lineages are MEK1, PDCD4, and SF2. Each is linked with MCAM in more than 1 cancer types. Because this analysis shows association rather than direction, both MCAM-to-partner and partner-to-MCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MCAM-low versus MCAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAM→partner) and Y-score (partner→MCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.613	+2.736	<.001	<.001	3	2
UCEC	PDCD4 →	-0.483	-1.502	.005	.030	3	2
BLCA	SF2 →	+0.260	+3.169	.005	.019	3	1
UCEC	eIF4E →	+0.210	+2.472	.006	.010	3	1
UCEC	ER-alpha_pS118 →	-0.322	-3.584	.014	.002	3	1
UCEC	A-Raf_pS299 →	-0.157	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MEK1 by MCAM expression — UCEC

Explore this box plot interactively →