MCAM

Across TCGA cell cohorts, MCAM RNA expression is significantly associated with the go_rna of many other GO terms, with 5,382 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MCAM-associated GO terms across cancer lineages are Regulation of cell-substrate junction assembly, Protein insertion into ER membrane, and Regulation of focal adhesion assembly. Each is linked with MCAM in more than 10 cancer types. Because this analysis shows association rather than direction, both MCAM-to-partner and partner-to-MCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction assembly grouped by MCAM-low versus MCAM-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAM→partner) and Y-score (partner→MCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of cell-substrate junction assembly →	+0.085	+3.194	<.001	<.001	3	11
URINARY_TRACT	Protein insertion into ER membrane →	+0.099	+2.568	.001	.006	3	11
LUNG_NSCLC_LUSC	Regulation of focal adhesion assembly →	+0.085	+3.194	<.001	<.001	3	11
OESOPHAGUS	Peptidyl-lysine oxidation →	+1.775	+3.160	<.001	<.001	3	10
BONE	Cellular response to environmental stimulus →	+0.055	+2.987	<.001	<.001	3	10
BREAST	Positive regulation of extracellular matrix organization →	+0.123	+2.361	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,382 associations by consensus.

Regulation of cell-substrate junction assembly by MCAM expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →