MCAM

Across TCGA cell cohorts, MCAM mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCAM-associated genes across cancer lineages are OTOR, LRIT2, and PRAMEF9. Each is linked with MCAM in more than 1 cancer types. Because this analysis shows association rather than direction, both MCAM-to-partner and partner-to-MCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOR grouped by MCAM-low versus MCAM-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAM→partner) and Y-score (partner→MCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOR →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	LRIT2 →	+0.027	+4.087	.001	.009	3	1
URINARY_TRACT	PRAMEF9 →	+0.010	+4.087	<.001	.009	3	1
LARGE_INTESTINE	PSMC6 →	+0.568	+3.064	<.001	.009	3	1
LARGE_INTESTINE	USP14 →	+0.698	+3.067	.004	.009	3	1
LARGE_INTESTINE	CLUAP1 →	+0.639	+3.215	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

OTOR by MCAM expression — URINARY_TRACT

Explore this box plot interactively →