MCAM

Across TCGA cell cohorts, MCAM mutation is significantly associated with the mutation status of many other genes, with 4,093 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCAM-associated genes across cancer lineages are SEMA5B, TRIO, and TRPM6. Each is linked with MCAM in more than 3 cancer types. Because this analysis shows association rather than direction, both MCAM-to-partner and partner-to-MCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMA5B grouped by MCAM-low versus MCAM-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCAM→partner) and Y-score (partner→MCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SEMA5B →	+3.307	+3.777	.005	.005	1	4
URINARY_TRACT	TRIO →	+3.672	+4.307	.004	.004	1	4
URINARY_TRACT	TRPM6 →	+4.672	+4.672	.001	.001	1	4
BLOOD_Leukemia	VCAN →	+2.548	+4.705	<.001	<.001	1	4
BLOOD_Leukemia	TCF20 →	+2.787	+3.962	<.001	<.001	1	4
LARGE_INTESTINE	C3 →	+1.895	+4.169	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,093 associations by consensus.

SEMA5B by MCAM expression — LUNG_SCLC

Explore this box plot interactively →