MC3R

Across TCGA pan-cancer cohorts, MC3R Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MC3R data layer compared with 16 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher MC3R Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MC3R expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LGG, STAD, and ACC are the cancer types where MC3R Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.083	0.833	<.001	12	view →
STAD	OS	Median	All	0.232	0.671	<.001	12	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
LUAD	OS	Median	All	0.545	0.793	.014	4	view →
SKCM	OS	Median	II,III,IV	0.936	0.723	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MC3R–LGG (DFS)

Open the LGG breakdown →