Across TCGA patient cohorts, MC2R mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MC2R-associated genes across cancer lineages are Dvl3, ERK2, and eEF2. Each is linked with MC2R in more than 2 cancer types. Because this analysis shows association rather than direction, both MC2R-to-partner and partner-to-MC2R results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC2R→partner) and Y-score (partner→MC2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Dvl3 →	+0.242	+3.009	.017	.019	3	3
LUAD	ERK2 →	+0.337	+2.820	.048	.035	3	3
UCEC	eEF2 →	+0.344	+2.000	.014	.010	3	3
LUSC	MSH6 →	+0.499	+3.009	.018	.019	3	2
UCEC	Notch1 →	+0.185	+1.710	<.001	.025	3	2
UCEC	Shc_pY317 →	-0.198	-2.807	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

MC2R survival (RNA) · tumor vs normal (RNA) · all MC2R data types