Across TCGA cell cohorts, MC2R RNA expression is significantly associated with the RNA expression of many other genes, with 962 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible MC2R-associated genes across cancer lineages are SPATA31A6, OR4A47, and PRAMEF18. Each is linked with MC2R in more than 2 cancer types. Because this analysis shows association rather than direction, both MC2R-to-partner and partner-to-MC2R results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC2R→partner) and Y-score (partner→MC2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SPATA31A6 →	+0.193	+0.014	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	OR4A47 →	+0.125	+0.034	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PRAMEF18 →	+0.209	+0.029	<.001	<.001	3	3
BLOOD_Lymphoma	MS4A13 →	+0.365	+0.009	<.001	<.001	3	3
STOMACH	LACTBL1 →	+0.066	+0.004	<.001	.003	3	3
LARGE_INTESTINE	SMIM9 →	+0.130	+0.011	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 962 associations by consensus.

Exploration

MC2R survival (RNA) · tumor vs normal (RNA) · all MC2R data types