Across TCGA cell cohorts, MC2R RNA expression is significantly associated with the mutation status of many other genes, with 161 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MC2R-associated genes across cancer lineages are SCN11A, ADGRF2, and DCAF8L1. Each is linked with MC2R in more than 1 cancer types. Because this analysis shows association rather than direction, both MC2R-to-partner and partner-to-MC2R results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC2R→partner) and Y-score (partner→MC2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SCN11A →	+3.969	+0.003	.009	<.001	3	2
BLOOD_Leukemia	ADGRF2 →	+4.384	+0.003	.006	<.001	3	2
BLOOD_Leukemia	DCAF8L1 →	+3.969	+0.003	.009	<.001	3	2
BLOOD_Leukemia	IFIH1 →	+4.384	+0.003	.006	<.001	3	2
CNS	MICAL1 →	+4.754	+0.004	.005	<.001	3	2
SOFT_TISSUE	SEMA5A →	+5.977	+0.073	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 161 associations by consensus.

Exploration

MC2R survival (RNA) · tumor vs normal (RNA) · all MC2R data types