Across TCGA cell cohorts, MC2R mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MC2R-associated genes across cancer lineages are MYL10, SERPINA7, and LCE3D. Each is linked with MC2R in more than 1 cancer types. Because this analysis shows association rather than direction, both MC2R-to-partner and partner-to-MC2R results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC2R→partner) and Y-score (partner→MC2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MYL10 →	+0.055	+3.523	.007	.008	3	1
LUNG_SCLC	SERPINA7 →	+0.045	+3.817	<.001	.004	3	1
LUNG_SCLC	LCE3D →	+0.050	+3.817	.001	.004	3	1
LUNG_SCLC	TSBP1 →	+0.042	+3.898	.003	.005	3	1
LUNG_SCLC	BHLHA9 →	+0.046	+3.817	<.001	.004	3	1
LUNG_SCLC	LEUTX →	+0.060	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

MC2R survival (RNA) · tumor vs normal (RNA) · all MC2R data types