MC1R

Across TCGA patient cohorts, MC1R RNA expression is significantly associated with the protein abundance of many other proteins, with 8,430 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MC1R-associated proteins across cancer lineages are CHMP1A, EHBP1L1, and RPRD2_T732. Each is linked with MC1R in more than 2 cancer types. Because this analysis shows association rather than direction, both MC1R-to-partner and partner-to-MC1R results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MC1R versus CHMP1A in LSCC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MC1R→partner) and Y-score (partner→MC1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHMP1A →	+0.295	+0.634	.001	<.001	3	3
HNSC	EHBP1L1 →	-0.385	-0.486	<.001	.007	3	3
LSCC	RPRD2_T732 →	+0.531	+0.947	.001	<.001	3	3
HNSC	AIDA →	+0.303	+0.648	<.001	<.001	3	3
LSCC	TOR1B →	+0.247	+0.494	<.001	.001	3	3
LSCC	TRUB1 →	+0.288	+0.632	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,430 associations by consensus.

MC1R vs CHMP1A — LSCC

Explore this scatter interactively →