MC1R

Across TCGA patient cohorts, MC1R mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MC1R-associated genes across cancer lineages are Notch1, Cyclin-B1, and FoxM1. Each is linked with MC1R in more than 1 cancer types. Because this analysis shows association rather than direction, both MC1R-to-partner and partner-to-MC1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MC1R-low versus MC1R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC1R→partner) and Y-score (partner→MC1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.129	+1.847	.012	.008	3	2
UCEC	Cyclin-B1 →	+0.509	+1.847	.013	.008	3	2
UCEC	FoxM1 →	+0.191	+1.594	.044	.042	3	1
UCEC	JNK2 →	+0.145	+1.710	.046	.025	3	1
UCEC	Ku80 →	+0.205	+1.598	.018	.040	3	1
UCEC	MEK1 →	+0.291	+2.000	.030	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Notch1 by MC1R expression — UCEC

Explore this box plot interactively →