MC1R

Across TCGA cell cohorts, MC1R RNA expression is significantly associated with the go_rna of many other GO terms, with 4,444 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MC1R-associated GO terms across cancer lineages are Melanin biosynthetic process, Melanin metabolic process, and Calcium-independent cell-matrix adhesion. Each is linked with MC1R in more than 14 cancer types. Because this analysis shows association rather than direction, both MC1R-to-partner and partner-to-MC1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Melanin biosynthetic process grouped by MC1R-low versus MC1R-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MC1R→partner) and Y-score (partner→MC1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Melanin biosynthetic process →	+1.312	+1.555	<.001	<.001	3	15
BREAST	Melanin metabolic process →	+1.312	+1.555	<.001	<.001	3	15
LARGE_INTESTINE	Calcium-independent cell-matrix adhesion →	+0.164	+0.917	<.001	<.001	3	15
LIVER	UV-damage excision repair →	+0.102	+0.908	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.157	-1.821	<.001	<.001	3	13
OESOPHAGUS	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.159	+1.467	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,444 associations by consensus.

Melanin biosynthetic process by MC1R expression — BREAST

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