MBTPS2

Across TCGA patient cohorts, MBTPS2 mutation is significantly associated with the RNA expression of many other genes, with 2,716 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBTPS2-associated genes across cancer lineages are TOMM22P1, RN7SKP286, and LILRA4. Each is linked with MBTPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBTPS2-to-partner and partner-to-MBTPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOMM22P1 grouped by MBTPS2-low versus MBTPS2-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBTPS2→partner) and Y-score (partner→MBTPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	TOMM22P1 →	+0.094	+5.450	<.001	.004	3	2
UCEC	RN7SKP286 →	+0.032	+3.558	<.001	.001	3	2
UCEC	LILRA4 →	+0.235	+1.669	.001	.001	3	2
UCEC	ZMYND19 →	+0.473	+2.131	<.001	<.001	3	2
UCEC	TMEM11 →	+0.350	+2.131	<.001	<.001	3	2
SCLC	UBE2U →	+0.255	+4.847	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,716 associations by consensus.

TOMM22P1 by MBTPS2 expression — ESCA

Explore this box plot interactively →