MBTPS2

Across TCGA patient cohorts, MBTPS2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBTPS2-associated genes across cancer lineages are S6_pS240_S244, ATM, and Dvl3. Each is linked with MBTPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBTPS2-to-partner and partner-to-MBTPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by MBTPS2-low versus MBTPS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBTPS2→partner) and Y-score (partner→MBTPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.353	+1.523	.006	.008	3	2
UCEC	ATM →	-0.427	-1.893	.003	.014	3	2
BRCA	Dvl3 →	+0.288	+2.814	.014	.037	3	1
UCEC	14-3-3_beta →	-0.105	-2.880	.001	.001	3	1
UCEC	eEF2 →	+0.280	+2.115	.014	.016	3	1
UCEC	EGFR_pY1068 →	-0.219	-1.289	.006	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

S6_pS240_S244 by MBTPS2 expression — UCEC

Explore this box plot interactively →