MBTPS2

Across TCGA cell cohorts, MBTPS2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBTPS2-associated genes across cancer lineages are TAS2R7, TAS2R60, and SSMEM1. Each is linked with MBTPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBTPS2-to-partner and partner-to-MBTPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R7 grouped by MBTPS2-low versus MBTPS2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBTPS2→partner) and Y-score (partner→MBTPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TAS2R7 →	+0.155	+3.736	<.001	.007	3	1
LUNG_SCLC	TAS2R60 →	+0.752	+4.058	<.001	.007	3	1
LARGE_INTESTINE	SSMEM1 →	+0.029	+4.029	<.001	.002	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2J2 →	+0.016	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TAS2R7 by MBTPS2 expression — LUNG_SCLC

Explore this box plot interactively →