MBTPS1

Across TCGA patient cohorts, MBTPS1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBTPS1-associated genes across cancer lineages are JNK_pT183_Y185, PCNA, and 4E-BP1_pT70. Each is linked with MBTPS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MBTPS1-to-partner and partner-to-MBTPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MBTPS1-low versus MBTPS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBTPS1→partner) and Y-score (partner→MBTPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.105	-1.517	.039	.004	3	3
UCEC	PCNA →	+0.154	+1.847	.018	.007	3	3
UCEC	4E-BP1_pT70 →	+0.075	+2.000	.031	.029	3	3
COAD	CD49b →	+0.429	+2.815	.008	.036	3	3
UCEC	EGFR_pY1068 →	-0.229	-1.754	.002	.001	3	2
UCEC	Lck →	+0.138	+1.125	.023	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK_pT183_Y185 by MBTPS1 expression — UCEC

Explore this box plot interactively →