MBTPS1

Across TCGA cell cohorts, MBTPS1 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,871 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MBTPS1-associated GO terms across cancer lineages are Negative regulation of icosanoid secretion, Epithelial cell fate commitment, and Negative regulation of fatty acid transport. Each is linked with MBTPS1 in more than 8 cancer types. Because this analysis shows association rather than direction, both MBTPS1-to-partner and partner-to-MBTPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of icosanoid secretion grouped by MBTPS1-low versus MBTPS1-high in LUNG_NSCLC_LUAD.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MBTPS1→partner) and Y-score (partner→MBTPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of icosanoid secretion →	+0.558	+0.811	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Epithelial cell fate commitment →	+0.132	+0.527	.001	.009	3	6
BLOOD_Lymphoma	Negative regulation of fatty acid transport →	+0.222	+1.312	<.001	<.001	3	6
BLOOD_Lymphoma	Regulation of plasminogen activation →	+0.281	+1.235	<.001	<.001	3	5
BREAST	Negative regulation of Arp2/3 complex-mediated actin nucleation →	-0.113	-1.299	.007	.001	2	6
LUNG_NSCLC_LUAD	Antimicrobial humoral immune response mediated by antimicrobial peptide →	-0.102	-0.719	.008	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,871 associations by consensus.

Negative regulation of icosanoid secretion by MBTPS1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →