MBTPS1

Across TCGA cell cohorts, MBTPS1 mutation is significantly associated with the RNA expression of many other genes, with 323 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBTPS1-associated genes across cancer lineages are CASP8AP2, DESI2, and FAM102B. Each is linked with MBTPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBTPS1-to-partner and partner-to-MBTPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CASP8AP2 grouped by MBTPS1-low versus MBTPS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBTPS1→partner) and Y-score (partner→MBTPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CASP8AP2 →	+0.631	+3.064	.001	.009	3	2
LARGE_INTESTINE	DESI2 →	+0.496	+3.364	.003	.002	3	2
LARGE_INTESTINE	FAM102B →	+1.020	+3.364	<.001	.002	3	2
LARGE_INTESTINE	PRMT9 →	+0.564	+3.192	.001	.007	3	2
LARGE_INTESTINE	ZFAND4 →	+0.818	+3.364	.002	.002	3	2
LARGE_INTESTINE	GEMIN2 →	+0.798	+3.364	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 323 associations by consensus.

CASP8AP2 by MBTPS1 expression — LARGE_INTESTINE

Explore this box plot interactively →