MBTPS1

Across TCGA cell cohorts, MBTPS1 mutation is significantly associated with the mutation status of many other genes, with 4,049 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBTPS1-associated genes across cancer lineages are MLLT6, MAP1B, and PNPLA6. Each is linked with MBTPS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MBTPS1-to-partner and partner-to-MBTPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLLT6 grouped by MBTPS1-low versus MBTPS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBTPS1→partner) and Y-score (partner→MBTPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MLLT6 →	+2.493	+2.758	.007	.007	1	5
LARGE_INTESTINE	MAP1B →	+1.684	+2.676	.001	.001	1	5
PANCREAS	PNPLA6 →	+5.115	+5.115	.005	.005	1	4
UPPER_AERODIGESTIVE_TRACT	RPS6KA1 →	+5.193	+4.539	<.001	<.001	1	4
SOFT_TISSUE	DEF8 →	+5.502	+5.502	.003	.003	1	4
SOFT_TISSUE	EPS8L3 →	+5.502	+5.502	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,049 associations by consensus.

MLLT6 by MBTPS1 expression — BLOOD_Leukemia

Explore this box plot interactively →