Across TCGA patient cohorts, MBP mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBP-associated genes across cancer lineages are Notch1, 4E-BP1, and Di-Ras3. Each is linked with MBP in more than 1 cancer types. Because this analysis shows association rather than direction, both MBP-to-partner and partner-to-MBP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBP→partner) and Y-score (partner→MBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.210	+2.087	<.001	.005	3	2
UCEC	4E-BP1 →	+0.286	+2.351	.005	.018	3	2
UCEC	Di-Ras3 →	-0.159	-2.687	.005	.005	3	2
UCEC	eEF2 →	+0.327	+3.321	.017	.009	3	1
UCEC	eIF4E →	+0.209	+2.087	.009	.005	3	1
UCEC	eIF4G →	+0.283	+2.584	.017	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

MBP survival (RNA) · tumor vs normal (RNA) · all MBP data types