Across TCGA cell cohorts, MBP mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBP-associated genes across cancer lineages are ARL6, SEMG2, and SH3GL3. Each is linked with MBP in more than 1 cancer types. Because this analysis shows association rather than direction, both MBP-to-partner and partner-to-MBP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBP→partner) and Y-score (partner→MBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARL6 →	+0.569	+3.212	.001	.006	3	1
LARGE_INTESTINE	SEMG2 →	+0.425	+3.556	<.001	<.001	3	1
LARGE_INTESTINE	SH3GL3 →	+0.842	+3.539	.001	.004	3	1
LARGE_INTESTINE	TRMT10A →	+0.634	+3.212	.004	.006	3	1
LARGE_INTESTINE	POM121L2 →	+0.066	+2.761	.009	.004	3	1
LARGE_INTESTINE	HTR1E →	+0.045	+2.760	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

MBP survival (RNA) · tumor vs normal (RNA) · all MBP data types