MBNL3

Across TCGA pan-cancer cohorts, MBNL3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MBNL3 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MBNL3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MBNL3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where MBNL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.680	.007	6	view →
UCEC	OS	Median	II,III,IV	1.000	0.583	.033	4	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.877	.042	2	view →
PDAC	DFS	Median	All	0.476	0.316	.040	2	view →
HNSC	DFS	Tertile	IV	0.812	0.598	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MBNL3–CCRCC (OS)

Open the CCRCC breakdown →