MBNL1

Across TCGA pan-cancer cohorts, MBNL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MBNL1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MBNL1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MBNL1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where MBNL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.777	0.909	.002	62	view →
CCRCC	DFS	Tertile	All	0.589	0.910	.002	37	view →
LUAD	DFS	Median	All	0.948	0.889	.018	9	view →
PDAC	OS	Median	All	0.459	0.276	.003	9	view →
GBM	OS	Quartile	All	0.548	0.206	.033	2	view →
LSCC	OS	Median	All	0.815	0.913	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MBNL1–HNSC (OS)

Open the HNSC breakdown →