MBNL1

Across TCGA patient cohorts, MBNL1 mutation is significantly associated with the RNA expression of many other genes, with 3,970 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBNL1-associated genes across cancer lineages are HMGB1P22, TRIM49C, and EIF3JP1. Each is linked with MBNL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MBNL1-to-partner and partner-to-MBNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P22 grouped by MBNL1-low versus MBNL1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBNL1→partner) and Y-score (partner→MBNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	HMGB1P22 →	+0.297	+3.565	<.001	.007	3	3
UCEC	TRIM49C →	+0.116	+1.446	.007	.008	3	2
UCEC	EIF3JP1 →	+0.132	+1.690	<.001	.003	3	2
UCEC	TRIM53CP →	+0.335	+1.898	<.001	<.001	3	2
LIHC	RNA5SP393 →	+0.483	+5.940	<.001	<.001	3	2
LUSC	LINC02857 →	+0.363	+3.592	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,970 associations by consensus.

HMGB1P22 by MBNL1 expression — LUSC

Explore this box plot interactively →