MBNL1

Across TCGA cell cohorts, MBNL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,026 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MBNL1-associated GO terms across cancer lineages are Negative regulation of protein-containing complex disassembly, Double-strand break repair via nonhomologous end joining, and Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Each is linked with MBNL1 in more than 11 cancer types. Because this analysis shows association rather than direction, both MBNL1-to-partner and partner-to-MBNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein-containing complex disassembly grouped by MBNL1-low versus MBNL1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MBNL1→partner) and Y-score (partner→MBNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of protein-containing complex disassembly →	+0.072	+0.695	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.070	+0.950	<.001	<.001	3	12
BONE	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.072	+1.128	<.001	<.001	3	11
BONE	Regulation of angiotensin-activated signaling pathway →	+0.205	+0.932	<.001	.005	3	11
BONE	Phosphatidylinositol metabolic process →	+0.046	+1.019	<.001	.001	3	11
LUNG_NSCLC_LUSC	Negative regulation of plasma membrane bounded cell projection assembly →	+0.047	+0.670	.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,026 associations by consensus.

Negative regulation of protein-containing complex disassembly by MBNL1 expression — SOFT_TISSUE

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