MBLAC2

Across TCGA patient cohorts, MBLAC2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBLAC2-associated genes across cancer lineages are ASNS, 14-3-3_beta, and eIF4E. Each is linked with MBLAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBLAC2-to-partner and partner-to-MBLAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MBLAC2-low versus MBLAC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBLAC2→partner) and Y-score (partner→MBLAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.443	+2.906	.001	.001	3	2
UCEC	14-3-3_beta →	-0.096	-1.752	.011	.014	3	1
UCEC	eIF4E →	+0.202	+2.662	.010	<.001	3	1
UCEC	eIF4G →	+0.334	+2.662	.004	<.001	3	1
UCEC	FASN →	+0.312	+2.584	.035	.010	3	1
UCEC	FoxM1 →	+0.235	+1.765	.015	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by MBLAC2 expression — UCEC

Explore this box plot interactively →