MBL2

Across TCGA pan-cancer cohorts, MBL2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MBL2 data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MBL2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MBL2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where MBL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.345	1.000	.010	20	view →
LSCC	DFS	Median	All	0.814	0.581	.003	18	view →
LUAD	OS	Quartile	All	0.913	1.000	.011	18	view →
PDAC	OS	Median	III,IV	0.302	0.598	.009	14	view →
CCRCC	DFS	Median	III,IV	0.856	0.553	.008	5	view →
GBM	DFS	Quartile	All	0.515	0.215	.026	2	view →
HNSC	DFS	Median	IV	1.000	0.927	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MBL2–UCEC (DFS)

Open the UCEC breakdown →