MBIP

Across TCGA patient cohorts, MBIP mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBIP-associated genes across cancer lineages are EGFR_pY1068, Shc_pY317, and VHL. Each is linked with MBIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MBIP-to-partner and partner-to-MBIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MBIP-low versus MBIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBIP→partner) and Y-score (partner→MBIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.340	-3.169	.013	.020	3	1
UCEC	Shc_pY317 →	-0.224	-3.169	.007	.020	3	1
UCEC	VHL →	-1.144	-3.000	.002	.036	3	1
UCEC	Caspase-8 →	-0.327	-3.000	.018	.036	2	1
UCEC	C-Raf_pS338 →	-0.105	-3.169	.019	.020	2	1
UCEC	A-Raf_pS299 →	-0.213	-3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by MBIP expression — UCEC

Explore this box plot interactively →