MBD6

Across TCGA patient cohorts, MBD6 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD6-associated genes across cancer lineages are ACC1, INPP4B, and MEK1. Each is linked with MBD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD6-to-partner and partner-to-MBD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by MBD6-low versus MBD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD6→partner) and Y-score (partner→MBD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.317	+2.013	.003	.004	3	2
UCEC	INPP4B →	-0.239	-1.584	.012	.015	3	2
UCEC	MEK1 →	+0.492	+2.099	<.001	<.001	3	2
UCEC	Mre11 →	-0.079	-1.880	.001	.014	3	2
UCEC	Rictor_pT1135 →	-0.082	-2.247	.006	.001	3	2
UCEC	S6_pS240_S244 →	+0.330	+1.058	.005	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

ACC1 by MBD6 expression — UCEC

Explore this box plot interactively →