Across TCGA patient cohorts, MBD5 mutation is significantly associated with the RNA expression of many other genes, with 8,229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD5-associated genes across cancer lineages are CPSF4, TOP3A, and MYO19. Each is linked with MBD5 in more than 4 cancer types. Because this analysis shows association rather than direction, both MBD5-to-partner and partner-to-MBD5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD5→partner) and Y-score (partner→MBD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CPSF4 →	+0.363	+1.595	<.001	<.001	3	5
UCEC	TOP3A →	+0.633	+2.938	<.001	<.001	3	5
UCEC	MYO19 →	+0.584	+1.898	<.001	<.001	3	4
UCEC	PLBD2 →	+0.345	+1.462	<.001	<.001	3	4
UCEC	NCAPD3 →	+0.766	+1.747	<.001	<.001	3	4
UCEC	TSPAN7 →	-0.898	-1.738	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,229 associations by consensus.

Exploration

MBD5 survival (RNA) · tumor vs normal (RNA) · all MBD5 data types