Across TCGA patient cohorts, MBD5 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD5-associated genes across cancer lineages are PREX1, ACC1, and mTOR_pS2448. Each is linked with MBD5 in more than 3 cancer types. Because this analysis shows association rather than direction, both MBD5-to-partner and partner-to-MBD5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD5→partner) and Y-score (partner→MBD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PREX1 →	-0.285	-1.938	.002	.001	3	4
UCEC	ACC1 →	+0.237	+1.428	.015	.025	3	3
UCEC	mTOR_pS2448 →	-0.097	-1.446	.015	.009	3	3
UCEC	4E-BP1 →	+0.346	+2.584	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.584	+2.392	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.119	+1.000	.008	.026	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration

MBD5 survival (RNA) · tumor vs normal (RNA) · all MBD5 data types