Across TCGA cell cohorts, MBD5 mutation is significantly associated with the RNA expression of many other genes, with 193 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBD5-associated genes across cancer lineages are OR5AN1, SPATA31E1, and MYF6. Each is linked with MBD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD5-to-partner and partner-to-MBD5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD5→partner) and Y-score (partner→MBD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR5AN1 →	+0.019	+3.963	.009	.003	3	2
CNS	SPATA31E1 →	+0.082	+3.432	<.001	.007	3	2
PANCREAS	MYF6 →	+0.005	+4.614	<.001	.004	3	1
LUNG_NSCLC_LUSC	TMCO2 →	+0.058	+3.807	<.001	.003	3	1
URINARY_TRACT	GADL1 →	+0.010	+4.050	.002	.002	3	1
URINARY_TRACT	BTBD17 →	+0.021	+4.050	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 193 associations by consensus.

Exploration

MBD5 survival (RNA) · tumor vs normal (RNA) · all MBD5 data types