MBD4

Across TCGA patient cohorts, MBD4 mutation is significantly associated with the RNA expression of many other genes, with 2,473 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD4-associated genes across cancer lineages are MIR1252, ATP5PFP1, and RNU6-1326P. Each is linked with MBD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MBD4-to-partner and partner-to-MBD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1252 grouped by MBD4-low versus MBD4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD4→partner) and Y-score (partner→MBD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR1252 →	+0.544	+5.683	<.001	.004	3	3
CESC	ATP5PFP1 →	+0.197	+3.575	.004	.009	3	3
STAD	RNU6-1326P →	+0.321	+5.928	<.001	.002	3	3
CESC	RNU6-1067P →	+0.422	+4.569	<.001	.005	3	2
BRCA	TTTY7B →	+0.016	+7.471	<.001	.008	3	2
BRCA	OR5M5P →	+0.110	+5.610	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,473 associations by consensus.

MIR1252 by MBD4 expression — BRCA

Explore this box plot interactively →