MBD4

Across TCGA patient cohorts, MBD4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD4-associated genes across cancer lineages are MEK1, EGFR_pY1068, and Myosin-IIa_pS1943. Each is linked with MBD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD4-to-partner and partner-to-MBD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MBD4-low versus MBD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD4→partner) and Y-score (partner→MBD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.367	+2.087	.008	.005	3	2
UCEC	EGFR_pY1068 →	-0.212	-2.087	.027	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.167	+1.691	.035	.014	3	1
UCEC	Notch1 →	+0.151	+1.750	.005	.049	3	1
UCEC	Rab25 →	-0.322	-1.678	.011	.023	3	1
UCEC	Annexin-1 →	+0.636	+2.479	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MEK1 by MBD4 expression — UCEC

Explore this box plot interactively →